Warning: A non-numeric value encountered in /home/customer/www/costa-lab.org/public_html/wp-content/themes/Divi/functions.php on line 5841


Botta P, Fushiki A, Vicente AM, Hammond LA, Mosberger AC, Gerfen CR, Peterka D, Costa RM (2020). An Amygdala Circuit Mediates Experience-Dependent Memory Arrests during Exploration. Cell, in press. (doi:10.1016/j.cell.2020.09.023)

Fernandes AB, Alves da Silva J, Almeida J, Cui G, Gerfen CR, Costa RM, Oliveira-Maia A (2020). Postingestive modulation of food seeking depends on vagal-mediated dopamine neuron activity. Neuron, 106(5):778 – 788.e6. (doi: 10.1016/j.neuron.2020.03.009)

     Godinho-Silva C, Domingues RG, Rendas M, Raposo B, Ribeiro H, Silva JA, Vieria A, Costa RM, Barbosa-Morais NL, Carvalho T, Veiga-Fernandes H (2019). Light-entrained and brain-tuned circadian circuits regulate ILC3 and gut homeostasis. Nature, 574:254-258. (doi: 10.1038/s41586-019-1579-3)

     Rao-Ruiz P, Couey JJ, Marcelo IM, Bouwkamp CG, Slump DE, Matos MR, van der Loo RJ, Martins GJ, van den Hout M, van IJcken WF, Costa RM, van den Oever MC, Kushner SA (2019). Engram-specific transcriptome profiling of contextual memory consolidation. Nature Communications. 10; 2232. (doi: 10.1038/s41467-019-09960-x)

French CA, Veloz MV, Zhou K, Fisher SE, Costa RM, deZeeuw CI (2019). Differential effects of Foxp2 disruption in distinct motor circuitsMolecular Psychiatry, 24:447-462. (doi: 10.1038/s41380-018-0199-x)

Athalye VR, Santos FJ, Carmena JM, Costa RM (2018). Evidence for a neural law of effect. Science, 359(6379): 1024-1029(doi:10.1126/science.aao6058).

Neely RM, Koralek AC, Athalye VR, Costa RM, Carmena JM (2018). Volitional modulation of primary visual cortex activity requires the basal ganglia. Neuron, in press. (doi:10.1016/j.neuron.2018.01.051)

Silva JA, Tecuapetla F, Paixão VB, Costa, RM (2017). Dopamine neuron activity before action initiation gates and invigorates future movements. Nature, 554: 244-248. (doi:10.1038/nature25457)

Rijo-Ferreira F, Carvalho T, Afonso C, Sanches-Vaz M, Costa RM, Figueiredo LM, Takahashi JS (2018). Sleeping sickness is a circadian disorder. Nature Communications, 9(1):62. (doi:10.1038/s41467-017-02484-2)

Afonso C, Paixão VB, Klaus A, Lunghi M, Piro F, Emiliani C, di Cristina M, Costa RM (2017). Toxoplasmainduced changes in host risk behaviour are independent of parasite-derived AaaH2 tyrosine hydroxylase. Scientific Reports, 7(1):13822. (doi: 10.1038/s41598-017-13229-y)

Klaus A*, Martins GJM*, Paixão VB, Zhou P, Paninski L, Costa RM (2017). The spatiotemporal organization of the striatum encodes action space. Neuron, 95(5):1171-80. (doi: 10.1016/j.neuron.2017.08.015)

Galvão-Ferreira P, Lipinski M, Santos F, Barco A, Costa RM (2017). Skill Learning Modulates RNA Pol II Poising at Immediate Early Genes in the Adult Striatum. eNeuro, 17;4(2). (doi: 10.1523/ENEURO.0074-17.2017)

Athalye VR, Ganguly K, Costa RM*, Carmena JM* (2017). Emergence of Coordinated Neural Dynamics Underlies Neuroprosthetic Learning and Skillful Control. Neuron,  93(4):955-970.  (doi: 10.1016/j.neuron.2017.01.016) 

Tecuapetla F, Jin X., Lima SQ, Costa RM (2016). Complementary contributions of striatal projection pathways to action initiation and execution. Cell, 166(3):703-15. (doi: 10.1016/j.cell.2016.06.032)

Gremel CM, Chancey JH, Atwood BK, Luo G, Neve R, Ramakrishnan C, Deisseroth K, Lovinger DM, Costa RM. (2016) Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation. Neuron 90(6):1312-24  (doi:10.1016/j.neuron.2016.04.043)

Vicente AM, Galvão-Ferreira P, Tecuapetla F, Costa RM. (2016) Direct and indirect dorsolateral striatum pathways reinforce different action strategies Curr. Biol. 26 (7), R267–R269 (doi:10.1016/j.cub.2016.02.036)

Akam T, Costa R, Dayan P. (2015) Simple Plans or Sophisticated Habits? State, Transition and Learning Interactions in the Two-Step Task. PLoS Comput. Biol. 11 (12), e1004648 (doi:10.1371/journal.pcbi.1004648)

Barahona-Corrêa JB, Camacho M, Castro-Rodrigues P, Costa R, Oliveira-Maia AJ. (2015) From Thought to Action: How the Interplay Between Neuroscience and Phenomenology Changed Our Understanding of Obsessive-Compulsive Disorder Front Psychol 6:1798 (doi:10.3389/fpsyg.2015.01798)

Santos FJ, Oliveira RF, Jin X, Costa RM. (2015) Corticostriatal dynamics encode the refinement of specific behavioral variability during skill learning. eLife 4:e09423 (doi:10.7554/eLife.09423)

Jin X, Costa RM (2015) Shaping action sequences in basal ganglia circuits. Curr. Opin. Neurobiol. 33 , 188–196 (doi:10.1016/j.conb.2015.06.011)

Cao VY, Ye Y, Mastwal S, Ren M, Coon M, Liu Q, Costa RM, Wang KH. (2015) Motor Learning Consolidates Arc-Expressing Neuronal Ensembles in Secondary Motor Cortex Neuron 86 (6), 1385–1392 (doi:10.1016/j.neuron.2015.05.022)

Gomez-Marin A, Paton JJ, Kampff AR, Costa RM, Mainen ZF. (2014) Big behavioral data: psychology, ethology and the foundations of neuroscience Nat. Neurosci. (17), 1455–1462 (doi: 10.1038/nn.3812.)

Akam T, Costa RM (2014) When brains flip coins Neuron 84 (1), 9-11 (doi:10.1016/j.neuron.2014.09.025)

Tecuapetla F, Matias S, Dugue GP, Mainen ZF, Costa RM. (2014) Balanced activity in basal ganglia projection pathways is critical for contraversive movements Nat Commun (5), 4315 (doi: 10.1038/ncomms5315)

Cui G, Jun SB, Jin X, Luo G, Pham MD, Lovinger DM, Vogel SS, Costa RM (2014) Deep brain optical measurements of cell type–specific neural activity in behaving mice Nat Protoc. 9 (6), 1213-28 (doi:10.1038/nprot.2014.080)

Jin X, Tecuapetla F, Costa RM (2014) Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences Nat. Neurosci. 17(3):423-30 (doi:10.1038/nn.3632)

Gremel CM, Costa RM (2013) Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions. Nat Commun 4:2264 (doi:10.1038/ncomms3264)

Cui G, Jun SB, Jin X, Pham MD, Vogel SS, Lovinger DM, Costa RM (2013) Concurrent activation of striatal direct and indirect pathways during action initiation Nature 494 , 238–242 (doi:10.1038/nature11846)

Silva JA, Costa RM (2012) Bursting for exploration Nat. Neurosci. 15 (9), 1178-1179 (doi:10.1038/nn.3198)

Vicente AM, Costa RM (2012) Looking at the trees in the central forest: a new pallidal-striatal cell type. Neuron 74 (6), 967-9 (doi:10.1016/j.neuron.2012.06.003)

Dias-Ferreira E, Costa RM (2012) Neuroscience: The symphony of choice. Nature 484 (7392), 42-3 (doi:10.1038/484042a.)

Hilario M, Holloway T, Jin X, Costa RM. (2012) Different dorsal striatum circuits mediate action discrimination and action generalization. Eur J Neurosci. 35 (7), 1105-14 (doi:10.1111/j.1460-9568.2012.08073.x.)

Afonso C, Paixão VB, Costa RM (2012) Chronic Toxoplasma Infection Modifies the Structure and the Risk of Host Behavior. PLoS ONE 7 (3) (doi:10.1371/journal.pone.0032489)

Koralek AC, Jin X, Long JD 2nd, Costa RM, Carmena JM. (2012) Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills. Nature 483 (7389), 331-5 (doi:10.1038/nature10845.)

Santos FJ, Costa RM and Tecuapetla, F. (2011) Stimulation on Demand: Closing the Loop on Deep Brain Stimulation. Neuron 72 (2), 197-198 (doi:10.1016/j.neuron.2011.10.004)

French CA, Jin X, Campbell TG, Gerfen E, Groszer M, Fisher SE, Costa RM (2011) An Aetiological Foxp2 Mutation Causes Aberrant Activity and Synchrony of Striatal Circuits. Mol. Psychiatry 17(11):1077-85 (doi: 10.1038/mp.2011.105)

Costa RM (2011) A selectionist account of de novo action learning. Curr. Opin. Neurobiol. 21 (4), 579-86 (doi:10.1016/j.conb.2011.05.004)

Yin HH, Costa RM (2011) Striatal dopamine and glutamate in action: the generation and modification of adaptive behavior. in Front Neurosci, The Role of Dopamine in the Basal Ganglia, ed Susan Jones, Taylor & Francis Group, Boca Raton, FL, USA.

Koralek AC, Long JD, Costa RM, Carmena JM (2010) Corticostriatal dynamics during learning and performance of a neuroprosthetic task. Conf Proc IEEE Eng Med Biol Soc 1 , 2682-5 (doi:10.1109/IEMBS.2010.5626632)

Jin X, Costa RM (2010) Start/stop signals emerge in nigrostriatal circuits during sequence learning. Nature 466 , 457-62 (doi:10.1038/nature09263)

Derusso AL, Fan D, Gupta J, Shelest O, Costa RM, Yin HH (2010) Instrumental uncertainty as a determinant of behavior under interval schedules of reinforcement. Front Integr Neurosci 4 (17), 1-8 (doi:10.3389/fnint.2010.00017)

Venkatraman S, Jin X, Costa RM, Carmena JM (2010) Investigating neural correlates of behavior in freely behaving rodents using inertial sensors. J. Neurophysiol. 104 (1), 569-75 (doi:10.1152/jn.00121.2010)

Dias-Ferreira E, Sousa N and Costa RM (2010) Frontocerebellar Connectivity: Climbing through the Inferior Olive. Front Neurosci 4 (37) (doi:10.3389/fnins.2010.00037)

Lovinger DM, Davis MI and Costa RM (2009) Endocannabinoid Signaling in the Striatum. Handbook of Basal Ganglia Structure and Function 20 , 167-186 (doi:10.1016/B978-0-12-374767-9.00009-3)

Burkhardt JM, Jin X, and Costa RM (2009) Dissociable effects of dopamine on neuronal firing rate and synchrony in the dorsal striatum. Front Integr Neurosci 3 (28) (doi:10.3389/neuro.07.028.2009.)

Yin HH, Prasad-Mulcare S, Hilario MRF, Clouse E, Davis MI, Lovinger DM, Costa RM (2009) Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. Nat. Neurosci. 12 (3) (doi:10.1038/nn.2261)

Dias-Ferreira E, Sousa JC, Melo I, Morgado P, Mesquita AR, Cerqueira JJ, Costa RM Sousa N (2009) Chronic stress causes frontostriatal reorganization and impairs decision making. Science 325 (5940), 621-5 (doi:10.1126/science.1171203)

Hilário MRF and Costa RM (2008) High on Habits Front Neurosci 2 (2), 208-21 (doi:10.3389/neuro.01.030.2008)

Cui Y, Costa RM, Murphy GG, Elgersma Y, Zhu Y, Gutmann DH, Parada LF, Mody I, Silva AJ (2008) Neurofibromin regulation of Ras/ERK signaling modulates GABA release and learning. Cell 135 (3), 549-60 (doi:10.1016/j.cell.2008.09.060)

Groszer M, Keays DA, Deacon RMJ, de Bono JP, Prasad-Mulcare S, Gaub S, Baum MG, French CA, Nicod J, Coventry JA, Enard W, Fray M, Brown SDM, Nolan PM, Pääbo S, Channon KM, Costa RM, Eilers J, Ehret GJ, Rawlins NP, Fisher SE (2008) Impaired motor learning and synaptic plasticity in mice carrying a point mutation implicated in human speech deficits. Curr. Biol. 18 (5), 354-62 (doi:10.1016/j.cub.2008.01.060)

Hilario MRF, Clouse E, Yin HH, Costa RM (2007) Endocannabinoid signaling is critical for habit formation. Front Integr Neurosci 1 (6) (doi:10.3389/neuro.07/006.2007)

Wickens JR, Horvitz JC, Costa RM, Killcross S (2007) Dopaminergic mechanisms in actions and habits. J. Neurosci. 27 , 8181-3 (doi:10.1523/?JNEUROSCI.1671-07.2007)

Costa RM (2007) Plastic corticostriatal circuits for action learning: what’s dopamine got to do with it? Ann. N. Y. Acad. Sci. 1104 , 172-91 (doi:10.1196/annals.1390.015)

Costa RM, Lin SC, Sotnikova TD, Cyr M, Gainetdinov RR, Caron MG, Nicolelis MAL (2006) Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. Neuron 52 (2), 359-69 (doi:10.1016/j.neuron.2006.07.030)

Costa RM, Gutierrez R, Kloth A, Coelho MRP, de Araujo IE, Gainetdinov RR, Caron MG, Nicolelis MAL, Simon SA (2006) Dopamine levels modulate the updating of tastant values. Genes Brain Behav. 6 (4), 314-20 (doi:10.1111/j.1601-183X.2006.00257.x)

Dzirasa K, Ribeiro S, Costa R, Santos LM, Lin SC, Grosmark A, Sotnikova TD, Gainetdinov RR, Caron MG, Nicolelis MAL (2006) Dopaminergic Control of Sleep-Wake States. J. Neurosci. 26 (41), 10577-89 (10.1523/JNEUROSCI.1767-06.2006)

Nagy V, Bozdagi O, Matynia A, Balcerzyk M, Okulski P, Dzwonek J, Costa RM, Silva AJ, Kaczmarek L and Huntley GW (2006) Matrix metalloproteinase (MMP)-9 is required for hippocampal late-phase LTP and memory. J. Neurosci. 26 , 1923-1934 (doi: 10.1523/JNEUROSCI.4359-05.2006)

Costa RM, Drew C and Silva AJ (2005) To Remember or Notch to Remember. Trends Neurosci. 28 , 429-35 (doi:10.1016/j.tins.2005.05.003)

Costa RM, Liu L, Nicolelis MAL, Simon SA (2005) Gustatory Effects of Capsaicin that are Independent of TRPV1 Receptors. Chem. Senses 30 , 198-200 (doi:10.1093/chemse/bjh183)

Costa RM and Silva AJ (2004) Learning Deficits associated with NF1: from models to therapies. Neurofibromatose: Clínica, Genética e Terapêutica, Ed. Mauro Geller, Guanabara Koogan SA, Rio de Janeiro, Brazil (Portuguese).

Israely I, Costa RM, Silva AJ, Kosik K, Liu X (2004) Deletion of the neural specific protein Delta-Catenin leads to severe cognitive and synaptic dysfunction. Curr. Biol. 14 (18), 1657-63. (doi: 10.1016/j.cub.2004.08.065)

Costa RM*, Cohen D*, Nicolelis MAL (2004) Differential corticostriatal plasticity during fast and slow motor skill learning in mice. Curr. Biol. 14 (13), 1124-34. (doi:10.1016/j.cub.2004.06.053)

Costa RM, Honjo T, and Silva AJ (2003) Learning and memory deficits in Notch mutant mice. Curr. Biol. 13 (15), 1348-54. (doi:10.1016/S0960-9822(03)00492-5)

Ajay A, Costa RM, Irvin D, Patel A, Hu H, Kornblum H, Silva AJ, O’Dell T, and Colicelli J (2003) The RAS Effector RIN1 Modulates the Formation of Aversive Memories. J. Neurosci. 23 (3), 748-757.

Frankland PW, Ohno M, Takahashi E, Chen AP, Costa RM, Kushner SA and Silva AJ (2003) Synomics: Pharmacologically Regulated Induction of Silent Mutations PRISM: Combined pharmacological and genetic approaches for learning and memory. Neuroscientist 9, 104-9. (doi:10.1177/1073858403252225)

Costa RM, Elgersma Y and Silva AJ (2003) Modeling cognitive disorders: from genes to therapies. Genetics and Genomics of Neurobehavioral Disorders. (doi:10.1007/s00439-003-1061-y)

Costa RM and Silva AJ (2002) Mouse models of Neurofibromatosis type I: Bridging the GAP. Trends Neurosci. 9 (1), 19-23. (doi:10.1016/S1471-4914(02)00008-4)

Costa RM (2002) Molecular and cellular mechanisms of cognitive dysfunction in Neurofibromatosis type I. JCN 17, 622-626. (doi:10.1177/088307380201700813)

Givogri MI, Costa RM, Schonmann V, Howard S, Silva AJ, Campagnoni AT, Bongarzone ER (2002) The Jagged/Notch pathway is critical for oligodendrocyte differentiation and myelination in vivo. J. Neurosci. Res. 67 (3), 309-20.

Costa RM, Federov NB, Kogan JH, Murphy GG, Stern J, Ohno M, Kucherlapati R, Jacks T and Silva AJ (2002) Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature 415 , 526-30 (doi:10.1038/nature711)

Silva AJ, Elgersma Y and Costa RM (2001) From genes to therapies: the role of animal models. Clin Neurosci Res 1 (3), 187-193. (doi:10.1016/S1566-2772(01)00005-6)

Costa RM*, Yang T*, Huynh DP, Pulst SM, Viskochil DH, Silva AJ and Brannan CI (2001) Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of the Neurofibromatosis type I gene. Nat. Genet. 27 , 399-405. (doi:10.1038/86898)

Ohno M, Frankland PW, Chen PA, Costa RM and Silva AJ (2001) Inducible pharmacogenetic approaches to the study of learning and memory. Nat. Neurosci. 4 (12), 1238-1243. (doi:10.1038/nn771)

Silva AJ, Elgersma Y and Costa RM (1999) Molecular and Cellular Mechanisms of Cognitive Function: Implications for Psychiatric Disorders. Biol. Psychiatry 47 (3), 200-210.

Mayntz M and Costa R (1998) Effect of pharmacologically induced changes of ejection on suckling in Bos taurus. Physiol. Behav. 65 (1), 151-156. (doi:10.1016/S0031-9384(98)00161-9)

Costa R, Mayntz M and Sender G (1998) Changes of milk compounds and fatty acid composition during suckling meals and the effect of after-stimulation on fatty acid composition in cows’ milk. A pre-study. 53 (8), 430-434.